The classic reference on the synthesis of medicinal agents —now completely updated

The seventh volume in the definitive series that provides a quick yet thorough overview of the synthetic routes used to access specific classesof therapeutic agents, this volume covers approximately 220 new non-proprietary drug entities introduced since the publication of Volume 6.Many of these compoundsrepresent novel structural types firstidentified by sophisticated new cell-based assays. Specifically, a significant number of new antineoplastic and antiviral agents are covered.

Download

Table of contents:

Monocyclic and Acyclic Aliphatic Compounds.

Derivatives of Benzyl and Benzhydryl Alcohols and Amines.

Phenylethyl and Phenylpropylamines.

Arylalkanoic Acids and Their Derivatives.

Monocyclic Aromatic Compounds.

Steroids.

Polycyclic Aromatic and Hydro-aromatic Compounds.

Five-Membered Heterocycles.

Six-Membered Heterocycles.

Morphinoids.

Five-Membered Heterocycles Fused to One Benzene Ring.

Six-Membered Heterocycles Fused to One Benzene Ring.

Benzodiazepines.

Heterocycles Fused to Two Benzene Rings.

beta-Lactam Antibiotics.

Miscellaneous Fused Heterocycles.

Indexes.

Errata for Volume 1 of Organic Chemistry of Drug Synthesis.

Download

Table of Contents:

Alicyclic and Cyclic Compounds.

Phenethyl and Phenoxypropanolamines.

Arylaliphatic Compounds.

Monocyclic Aromatic Agents.

Polycyclic Aromatic Compounds.

Steroids.

Compounds Related to Morphine.

Five-Membered Heterocycles.

Six-Membered Heterocycles.

Five-Membered Heterocycles Fused to Benzene.

Benzofused Six-Membered Heterocycles.

Beta Lactams.

Miscellaneous Fused Heterocycles.

Indexes.

Download

Table of Contents:

Aliphatic and Alicyclic Compounds.

Monocyclic Aromatic Compounds.

Polycyclic Aromatic Compounds and Their Reduction Products.

Steroids.

Five-Membered Ring Heterocycles.

Six-Membered Ring Heterocycles.

Five-Membered Ring Benzofused Heterocycles.

Six-Membered Ring Benzofused Heterocycles.

Bicyclic Fused Heterocycles.

beta-Lactam Antibiotics.

Miscellaneous Heterocycles.

Indexes.

Download

Asymmetric synthesis remains a challenge to practicing scientists as the need for enantiomerically pure or enriched compounds continues to increase. Over the last decade, a large amount of literature has been published in this field. Principles and Applications of Asymmetric Synthesis consolidates and evaluates the most useful methodologies into a one-volume resource for the convenience of practicing scientists and students.

Authored by internationally renowned scientists in the field, this reliable reference covers more than 450 reactions and includes important stoichiometric as well as catalytic asymmetric reactions. The first chapter reviews the basic principles, common nomenclature, and analytical methods, and the remainder of the book is organized according to reaction type. The text examines such topics as:

Carbon-carbon bond formations involving carbonyls, enamines, imines, and enolates

Asymmetric C-O bond formations including epoxidation, dihydroxylation, and aminohydroxylation

Asymmetric synthesis using the Diels-Alder reaction and other cyclizations

Applications to the total synthesis of natural products

Use of enzymes in asymmetric synthesis

Practicing chemists in the pharmaceutical, fine chemical, and agricultural professions as well as graduate students will find that Principles and Applications of Asymmetric Synthesis affords comprehensive and current coverage.

Download:

http://rapidshare.com/files/............../PAAOAS.rar